2/15/25
Gene therapy is an evolving therapeutic innovation which involves adding, removing or altering selected genes within the DNA of our cells.
One study found that the mouse cytomegalovirus (MCMV) carrying exogenous TERT(telomerase reverse transcriptase) or FST(follistatin) genes extended median lifespan by 41.4% and 32.5%, respectively. CMV has been successfully used as both an intranasal and injectable gene therapy to increase longevity.
Another study used adeno-associated viruses delivering an inducible OSK transcription factor system in 124-week-old male mice, extending their median lifespan by 109% compared to wild-type controls while improving health markers. A notable increase in frailty scores indicated an enhancement in healthspan along with lifespan increase. In human keratinocytes with exogenous OSK, signs of age reversal were noted.
Another study used adeno-associated viruses delivering an inducible OSK transcription factor system in 124-week-old male mice, extending their median lifespan by 109% compared to wild-type controls while improving health markers. A notable increase in frailty scores indicated an enhancement in healthspan along with lifespan increase. In human keratinocytes with exogenous OSK, signs of age reversal were noted.
Additionally, anti-IL-11 administered to 75-week-old mice enhanced metabolism and muscle function, reducing aging signs. Genetic deletion of Il11 increased mouse lifespan by 24. 9% on average, with anti-IL-11 treatment extending median lifespan in male mice by 22.5% and female mice by 25%.
By: Evan Redmond, Pharm.D.
