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Allopurinol (Zyloprim)

How to Use


Take this medication by mouth with a glass of water.


If this medication upsets your stomach, you may take it with food or milk.


Take this medication at the same time each day.


If you miss a dose, take the dose as soon as you remember. If it is already almost time for your next dose, take only the next dose. Do not double up on your dose or take two doses at once.



Important Information



Be sure that your doctor is aware if you are pregnant, breastfeeding, have kidney or liver diseases, or have any allergies before taking this medicine.


Do not operate heavy machinery, drive, or do other tasks that require alertness or motor skills until you are aware of how this medication effects you.


Avoid alcohol consumption whenever possible.


Avoid standing or sitting down very quickly this can increase your chances of dizziness. Sit or stand up slowly especially when first starting this medicine.


Notify your doctor if you are taking vitamin C.


Contact your healthcare provider if you get the following symptoms: rash, soar throat, fever, chills, nausea and vomiting, difficulty passing urine or blood in your urine.



Side effects that should be immediately reported to your healthcare provider



Allergic reaction(hives, itching, swelling of the face or mouth), trouble breathing, muscle pain, any red blistering, loosening or peelings skin.



Other Side Effects


Nausea and vomiting.





Allopurinol is typically started at 100 mg daily. The dose is then titrated weekly according to the patient’s response.





Mild: 100-300 mg by mouth divided into 1-3 doses per day.


Moderate - Severe: 400-600 mg by mouth daily divided into 1-3 doses per day.



Calcium Renal Calculus


 200-300 mg by mouth divided into 1-3 doses per day.



Hyperuricemia prevention during chemotherapy or tumor lysis syndrome


Over 10 years old: 600-800 mg by mouth divided into 2-3 doses per day taken for 2-3 days with an increased fluid intake.


6-10 years old: 300 mg by mouth daily. This dose is adjusted after 48 hours depending on the patient’s response.


Less than 6 years old:  150 mg by mouth daily. This dose is adjusted after 48 hours depending on the patient’s response.






Allopurinol is a medication commonly used for gout, hyperuricemia and kidney conditions. This medication works by decreasing the levels or uric acid in your body, which leads to its beneficial effects. Allopurinol is a safe and well tolerated medication when used as prescribed.





1. Allopurinol oral tablets, allopurinol oral tablets. Toronto, ON: Apotex Inc; 2005.


2. Allopurinol oral tablet, allopurinol oral tablet. Jacksonville, FL, Ranbaxy: Pharmaceuticals Inc.(per DailyMed); 2011.

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