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Combivent (Albuterol/Ipatropium)



Combivent contains the active ingredients albuterol and ipatropium. Albuterol is a beta -2 agonist which allows the smooth muscle tissue of the lungs to relax and expand, increasing oxygen supply to the blood. Ipatropium is an anticholinergic agent which leads to bronchodilation within the lungs. Combivent is used to treat respiratory conditions such as COPD, emphysema and bronchitis.



How to Use


This medicine is used by inhalation through the mouth.


Take exactly as directed, do not take more than directed.


If you miss a dose, take it as soon as you can. If it is already almost time for your next dose, take only that next dose. Do not double up on any dose.





- Press the safety catch while pulling off the clear base, do not touch the piercing element in bottom.


- Write the “discard by” date on the device (3 months from date cartridge is inserted). CCCCCHECK


- Remove a cartridge from the box, push the narrow end into bottom of the inhaler. You can push the bottom of the cartridge against a firm service to lock it in place. The base of the cartridge will not be flush with the bottom of the device, it will protrude out of the bottom about 1/8th of an inch.


- Put the clear base back on device.


- Hold the inhaler vertically with the cap closed.


- Turn the clear base a half a turn until it clicks.


- Flip the cap off to open the device.


- To prime, hold mouthpiece away from your face and press the dose release button.


- Repeat the previous step until you can see the spray, then close the cap and repeat the 3 previous steps 3 more times to ensure it is ready(after this it will still be able to deliver 120 doses).


- If you haven’t used the device in 21 days, prime it as previously described. If it has not been used in 3 days, spray only once away from your face to prime.


- Turn the clear base until it clicks, flip the cap off, exhale slowly and fully, wrap your lips around the mouthpiece, press the dose release button and inhale slowly and deeply, hold your breath for 10 seconds, then close the cap.


-When the pointer enters the red, you have 7 days of usage left, at this point you should ensure that your refill will be ready to pick up.


- To clean the device, open the cap and wipe the mouthpiece with a clean damp cloth.


- Store the device in a dry area at room temperature, avoid storing it in any extreme temperatures.



Important Information


Check with your doctor or pharmacist to make sure you are using this medicine correctly.


Talk to your doctor if your symptoms do not improve or get worse.


This medication can make your mouth dry, drinking water, chewing sugarless gum, or sucking on candy can decrease this side effect. Notify your doctor if this problem is severe or persistent.


Do not operate heavy machinery, drive a car, or engage in other activity that requires fine motor skills until you are sure of how this medication affects you. This is because this medicine can cause dizziness and blurred vision.


Stand and sit slowly when you are first starting this medication to avoid dizziness.



Be sure that your prescribing doctor is aware if you have any of the the following conditions before taking this medication


Heart disease, high blood pressure, irregular heart beat, all heart conditions, history of allergic reactions, pregnancy, breastfeeding, trying to become pregnant.



Side effects that should be immediately reported to your healthcare provider


Allergic reaction(hives, itching, swelling of the face or mouth), trouble breathing, lightheadedness, fainting, fever, high blood pressure, heartbeat changes, chest pain, muscle weakness, muscle cramps, tingling, pain, or numbers in the hands or feet, vomiting.



Other Side Effects


Cough, blurred vision, difficulty passing urine, trouble sleeping, headache, nervousness, trembling, stuffy nose, runny nose, unusual tastes, upset stomach.



Adult Dose for COPD


Combivent Respimat: 1 inhalation 4 times per day.


Max Dose: 6 inhalations in 24 hours.


Nebulizer Solution(DuoNebs): Inhale one vial(3ml) by nebulizer 4 times per day.


Max Dose: 6 doses in 24 hours.


Inhalation Aerosol: 2 inhalations 4 times per day.


Max Dose: 12 inhalations in 24 hours.





1. Combivent Respimat (albuterol; ipratropium) inhalation spray [package inser]t. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2016.


2. DuoNeb (ipratropium bromide / albuterol sulfate) Inhalation Solution for Nebulizer [package insert]. Napa, CA: Dey; 2011.


3. Combivent® oral inhalation aerosol, ipratropium bromide and albuterol sulfate oral inhalation aerosol[package insert]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc (per FDA); 2012.

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