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Pantoprazole (Protonix)



Pantoprazole (Protonix) is a proton pump inhibitor which works by absorbing into the blood stream and eventually acting on the K+/H+ ATPase pump which secretes stomach acid from the stomach’s parietal cells. It is effective in the treatment of heartburn, ulcers, and other secretory conditions.



How to Use


Take this medication by mouth with water, it can be taken with or without food.


Do not crush break or chew the tablets.


Take it exactly as directed, do not take it more than directed.


If you miss a dose, take it as soon as you can. If it is already almost time for your next dose, take only that next dose. Do not double up on any dose.



Important Information


It may take a few days before this medicine begins to work. Talk to your doctor if your symptoms are not improving or are getting worse.


Your doctor may require blood work while taking this medicine.



Be sure that your prescribing doctor is aware if you have any of the the following conditions before taking this medication


Low magnesium levels, liver disease, pregnancy, allergic reaction history, breastfeeding, trying to become pregnant.



Side effects that should be immediately reported to your healthcare provider


Allergic reactions (hives, rashes, itching, swelling of the face or mouth), trouble breathing, bone pain, muscle pain, muscle spasms, joint pain, dark colored urine, heartbeat changes(fast heartbeat), seizures, tremors, yellowing of the skin or eyes, excessive fatigue, fever, sore throat, lightheadedness or fainting, chest pain, unusual bleeding or bruising.



Other Side Effects


Diarrhea, constipation, headache, nausea, dry mouth.



Adult Dose


Duodenal Ulcer Disease


40-80 mg by mouth once daily for  4-8 weeks.



Erosive Esophagitis


40 mg by mouth once daily for up to 8 weeks.



Mild Gastroesophageal Reflux Disease


20 mg by mouth once daily for 4 weeks.



Zollinger Ellison Syndrome (or other hypersecratory conditions)


40 mg by mouth twice daily.





1. Protonix delayed-release oral tablets, suspension, pantoprazole sodium delayed-release oral tablets, suspension[package insert]. Philadelphia, PA: Wyeth Pharmaceuticals Inc; 2009.


2. Protonix R) IV injection, pantoprazole sodium IV injection[package insert]. Philadelphia, PA: Wyeth Pharmaceuticals, Inc; 2007.


3. Protonix (pantoprazole) [package insert]. Philadelphia, PA: Wyeth Pharmaceuticals, Inc.; 2014 Dec.

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