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Premarin(conjugated estrogens)



Premarin(conjugated estrogens) is a form of estrogen that fulfills all of the functions of the estrogen that the human body naturally produces. It is used to treat conditions such as menopause, hot flashes, osteoporosis prevention, and others.


How to Use


Take this medication by mouth with water. Take it at the same time every day.


Take it exactly as directed, do not take it more than directed.


If you miss a dose, take it as soon as you can. If it is already almost time for your next dose, take only that next dose. Do not double up on any dose.




Important Information


A medication guide will be given to you with this medicine, it is important to read this guide carefully.


Visit your doctor regularly, you will have a pelvic exam, pap smear, and breast exam regularly while taking this medicine. Your doctor may also require a mammogram regularly.


Contact your doctor if you experience swelling of the ankles, feet, or hands. This is a sign that you may be retaining fluid.


Notify your doctor if you believe you have become pregnant while taking this medicine.


Smoking can increase your chances of getting a blood clot or having a stroke while taking this medicine. It is strongly recommended to quit smoking.


Notify your eye doctor if you wear contact lenses and notice that your eyes are irritated or uncomfortable, or if you experience vision changes.


The tablet for some brands of this medicine dose not dissolve, therefore you may notice the shell is still whole within the stool. This is normal.


This medicine can increase your chances of developing endometrial hyperplasia. This is a condition of tissue growth which can lead to cancer of the uterus. Taking progestins along with this medicine can help to minimize this risk, however, could lead to other health risks. Discuss the risks and benefits of taking this medicine with and without progestins with your doctor to determine the best plan for you.


If you are getting surgery, inform your doctor or surgeon that you are taking this medicine, they may want you to stop taking it.



Be sure that your prescribing doctor is aware if you have any of the the following conditions before taking this medication


Abnormal vaginal bleeding, blood vessel or blood conditions, dementia, diabetes, endometriosis, high blood pressure, gallbladder disease, high cholesterol, high calcium levels, liver disease, kidney disease, depression, migraines, tobacco smoking, protein C or S deficiencies, history of stroke, history of allergic reactions, endometrial, ovarian, liver, uterine or cervical cancer.



Side effects that should be immediately reported to your healthcare provider


Allergic reactions (hives, rashes, itching, swelling of the face or mouth), trouble breathing, changes in breast tissue or discharge, vision changes, chest pain, confusion, trouble speaking, trouble understanding, darkened urine, flu like symptoms, light colored stools, nausea, vomiting, swelling or pain in the legs, pain in the upper right stomach, severe headaches, numbness or tingling in the extremities or face, lack of coordination, trouble walking, unusual vaginal bleeding, yellowing of the skin or eyes.



Other Side Effects


Increased hunger or thirst, hair loss, increased urination, vaginal irritation or discharge, excessive fatigue.



Adult Dose


Hormone Replacement for Moderate to Severe Menopause Symptoms


Oral Tablets: 0.3 mg by mouth once daily as a starting dose. This may be initiated as a continuous or cyclic therapy(25 days on, 5 days off). The dose is then adjusted according to the patient’s response.



Menopause Symptoms That are Exclusively Vaginal or Vulvar


Vaginal Cream: 0.5 mg vaginally once daily for 21 days, followed by no treatment for 7 days. The dose is repeated in cycles and adjusted according to patient response. The dose can be increased to up to 2 grams per day vaginally.



Estrogen Deficiency due to Hypogonadism in Premenopausal Females


0.3 mg or 0.625 mg by mouth once daily administered in cycles(3 weeks on, 1 week off). The dose is then adjusted based on patient response.



Osteoporosis Prophylaxis from estrogen deficiency(from natural or surgical menopause)


0.3 mg by mouth once daily as a starting dose. This may be initiated as a continuous or cyclic therapy(25 days on, 5 days off). The dose is then adjusted according to the patient’s response





1. Premarin (conjugated estrogens, equine tablets) [package insert]. Philadelphia, PA: Wyeth Pharmaceuticals Inc.; 2014.


2. Cenestin (synthetic conjugated estrogens) [package insert]. North Wales, PA: Teva Pharmaceuticals Inc.; 2015.


3. Synthetic conjugated estrogens, B (Enjuvia) [package insert]. North Wales, PA: Teva Women's Health, Inc.; 2015.


4. Premarin (R) oral tablets, conjugated estrogens oral tablets[package insert]. Philadelphia, PA: Wyeth Pharmaceuticals Inc. (per FDA); 2011.

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