Premarin(conjugated estrogens) is a form of estrogen that fulfills all of the functions of the estrogen that the human body naturally produces. It is used to treat conditions such as menopause, hot flashes, osteoporosis prevention, and others.
Take this medication by mouth with water. Take it at the same time every day.
Take it exactly as directed, do not take it more than directed.
A medication guide will be given to you with this medicine, it is important to read this guide carefully.
Visit your doctor regularly, you will have a pelvic exam, pap smear, and breast exam regularly while taking this medicine. Your doctor may also require a mammogram regularly.
Contact your doctor if you experience swelling of the ankles, feet, or hands. This is a sign that you may be retaining fluid.
Notify your doctor if you believe you have become pregnant while taking this medicine.
Smoking can increase your chances of getting a blood clot or having a stroke while taking this medicine. It is strongly recommended to quit smoking.
Notify your eye doctor if you wear contact lenses and notice that your eyes are irritated or uncomfortable, or if you experience vision changes.
The tablet for some brands of this medicine dose not dissolve, therefore you may notice the shell is still whole within the stool. This is normal.
This medicine can increase your chances of developing endometrial hyperplasia. This is a condition of tissue growth which can lead to cancer of the uterus. Taking progestins along with this medicine can help to minimize this risk, however, could lead to other health risks. Discuss the risks and benefits of taking this medicine with and without progestins with your doctor to determine the best plan for you.
If you are getting surgery, inform your doctor or surgeon that you are taking this medicine, they may want you to stop taking it.
Abnormal vaginal bleeding, blood vessel or blood conditions, dementia, diabetes, endometriosis, high blood pressure, gallbladder disease, high cholesterol, high calcium levels, liver disease, kidney disease, depression, migraines, tobacco smoking, protein C or S deficiencies, history of stroke, history of allergic reactions, endometrial, ovarian, liver, uterine or cervical cancer.
Allergic reactions (hives, rashes, itching, swelling of the face or mouth), trouble breathing, changes in breast tissue or discharge, vision changes, chest pain, confusion, trouble speaking, trouble understanding, darkened urine, flu like symptoms, light colored stools, nausea, vomiting, swelling or pain in the legs, pain in the upper right stomach, severe headaches, numbness or tingling in the extremities or face, lack of coordination, trouble walking, unusual vaginal bleeding, yellowing of the skin or eyes.
Increased hunger or thirst, hair loss, increased urination, vaginal irritation or discharge, excessive fatigue.
0.3 mg or 0.625 mg by mouth once daily administered in cycles(3 weeks on, 1 week off). The dose is then adjusted based on patient response.
0.3 mg by mouth once daily as a starting dose. This may be initiated as a continuous or cyclic therapy(25 days on, 5 days off). The dose is then adjusted according to the patient’s response
1. Premarin (conjugated estrogens, equine tablets) [package insert]. Philadelphia, PA: Wyeth Pharmaceuticals Inc.; 2014.
2. Cenestin (synthetic conjugated estrogens) [package insert]. North Wales, PA: Teva Pharmaceuticals Inc.; 2015.
3. Synthetic conjugated estrogens, B (Enjuvia) [package insert]. North Wales, PA: Teva Women's Health, Inc.; 2015.