Black Cohosh
Background
Black
cohosh, a member of the buttercup family, is a plant native to North
America. Native American and Chinese herbalists have traditionally used
black cohosh for a variety of ailments and as an
insect repellent.
Currently,
people use black cohosh as a dietary supplement for hot flashes and
other menopausal symptoms. It’s also been used as a dietary supplement
for other conditions, including menstrual cramps and premenstrual
syndrome, and to induce labor.
The part of the black cohosh
plant used in herbal preparations is the root or rhizome (underground
stem). Black cohosh is sold as the dried root, in tablets and capsules,
and as an extract.
How Much Do We Know?
Black cohosh
has been studied for menopause symptoms in people, but most of the
studies were not of the highest quality. Therefore, knowledge of the
effects of black cohosh is limited.
What Have We Learned?
Studies
that tested black cohosh for menopause symptoms have had inconsistent
results. The overall evidence is insufficient to support using black
cohosh for this purpose.
There are not enough reliable data to show whether black cohosh is
effective for other uses.
The
National Center for Complementary and Integrative Health (NCCIH) is
funding research to identify active components in black cohosh and
understand their effects in the body.
What Do We Know About Safety?
In
clinical trials, people have taken black cohosh for as long as 12
months with no serious harmful effects. The only reported side effects
were minor problems such as upset stomach or rashes.
Some
commercial black cohosh products have been found to contain the wrong
herb or to contain mixtures of black cohosh and other herbs that are
not listed on the label.
Cases of liver damage—some of them
very serious—have been reported in people taking commercial black
cohosh products. These problems are rare, and it is uncertain whether
black cohosh was responsible for them. Nevertheless, people with liver
disorders should consult a health care provider before taking black
cohosh products, and
anyone
who develops symptoms of liver trouble, such as abdominal pain, dark
urine, or jaundice, while taking black cohosh should stop using it and
consult a health care provider.
The risk of
interactions between black cohosh and medicines appears to be small.
NCCIH is funding research to learn more about possible interactions
involving black cohosh.
It’s not clear if black cohosh is safe
for women who have had hormone-sensitive conditions such as breast
cancer or for pregnant women or nursing mothers.
Black cohosh should not be confused with blue cohosh
(Caulophyllum thalictroides),
which has different effects and may not be safe. Black cohosh has
sometimes been used with blue cohosh to stimulate labor, but this use
was linked to severe adverse effects in at least one newborn.
Keep in Mind
Tell
all your health care providers about any complementary or integrative
health approaches you use. Give them a full picture of what you do to
manage your health. This will help ensure coordinated and
safe care.
Key References
Black
cohosh. Natural Medicines Web site. Accessed at
naturalmedicines.therapeuticresearch.com/ on March 31, 2015.
[Database subscription].
Borrelli F, Ernst E. Black
cohosh (Cimicifuga racemosa):
a systematic review of adverse events. American Journal of Obstetrics
and Gynecology. 2008;199(5):455-466.
Fabricant DS, Krause EC, Farnsworth NR. Black cohosh. In: Coates PM,
Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary
Supplements. 2nd
ed. New York, NY: Informa Healthcare; 2010:60-74.
Gurley BJ, Fifer EK, Gardner Z. Pharmacokinetic
herb-drug interactions (part 2): drug interactions involving popular
botanical dietary supplements and their clinical relevance. Planta Medica. 2012;78(13):1490-1514.
Jiang B, Kronenberg F, Nuntanakorn P, et al. Evaluation
of the botanical authenticity and phytochemical profile of black cohosh
products by high-performance liquid chromatography with selected ion
monitoring liquid chromatography-mass spectrometry. Journal of Agricultural and Food
Chemistry. 2006;54(9):3242-3253.
Leach MJ, Moore V. Black cohosh (Cimicifuga spp.) for menopausal
symptoms. Cochrane Database of Systematic
Reviews. 2012;(9):CD007244.
Accessed at http://www.thecochranelibrary.com/(link
is external) on
April 1, 2015.
Office of Dietary Supplements. Dietary Supplement Fact Sheet:
Black Cohosh. Office
of Dietary Supplements Web site. Accessed at http://ods.od.nih.gov/factsheets/BlackCohosh-HealthProfessional/ on
April 1, 2015.
Painter D, Perwaiz S, Murty M. Black cohosh products and liver
toxicity: update. Canadian Adverse Reaction
Newsletter. 2010;20(1):1-2.
Sarma ND, Giancaspro GI, Griffiths J, et al. Black
cohosh…more data, please! Menopause. 2011;18(4):350-351.
-NIH