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ADVAIR DISKUS- fluticasone propionate and salmeterol powder


  1. Patient Information
  2. Advair Diskus Is Used For Asthma And Copd As Follows:
  3. Do Not Use Advair Diskus:
  4. Advair Diskus Can Cause Serious Side Effects, Including:
  5. Symptoms Of Adrenal Insufficiency Include:
  6. Common Side Effects Of Advair Diskus Include:
  7. How Should I Store Advair Diskus?
  8. Active Ingredients:
  9. Inactive Ingredient:
  10. Important Information About Your Advair Diskus Inhaler:
  11. For Correct Use Of The Diskus, Remember:
  12. Active Ingredient(s):
  13. Inactive Ingredient(s):
  14. Revised: 4/2019document Id:

Patient Information 

Advise the patient to read the FDA-approved patient labeling (Patient Information and Instructions for Use).

Serious Asthma-Related Events

Inform patients with asthma that LABA when used alone increases the risk of asthma-related hospitalization or asthma-related death. Available data show that when ICS and LABA are used together, such as with ADVAIR DISKUS, there is not a significant increase in the risk of these events.

Not for Acute Symptoms

Inform patients that ADVAIR DISKUS is not meant to relieve acute asthma symptoms or exacerbations of COPD and extra doses should not be used for that purpose. Advise patients to treat acute symptoms with an inhaled, short-acting beta2-agonist such as albuterol. Provide patients with such medication and instruct them in how it should be used.

Instruct patients to

  • ADVAIR DISKUS combines the inhaled corticosteroid (ICS) medicine fluticasone propionate and the long-acting beta2-adrenergic agonist (LABA) medicine salmeterol.
    • ICS medicines such as fluticasone propionate help to decrease inflammation in the lungs. Inflammation in the lungs can lead to breathing problems.
    • LABA medicines such as salmeterol help the muscles around the airways in your lungs stay relaxed to prevent symptoms, such as wheezing, cough, chest tightness, and shortness of breath. These symptoms can happen when the muscles around the airways tighten. This makes it hard to breathe.
  • ADVAIR DISKUS is not used to relieve sudden breathing problemsand will not replace a rescue inhaler.
  • It is not known if ADVAIR DISKUS is safe and effective in children younger than 4 years.

Advair Diskus Is Used For Asthma And Copd As Follows: 

  • Asthma:
    1. ADVAIR DISKUS is a prescription medicine used to control symptoms of asthma and to prevent symptoms such as wheezing in adults and children aged 4 years and older.
    2. ADVAIR DISKUS contains salmeterol, the same medicine found in SEREVENT DISKUS (salmeterol xinafoate inhalation powder). LABA medicines such as salmeterol when used alone increase the risk of hospitalizations and death from asthma problems. ADVAIR DISKUS contains an ICS and a LABA. When an ICS and LABA are used together, there is not a significant increased risk in hospitalizations and death from asthma problems.
    3. ADVAIR DISKUS is not for adults and children with asthma who are well controlled with an asthma control medicine, such as a low to medium dose of an ICS medicine. ADVAIR DISKUS is for adults and children with asthma who need both an ICS and LABA medicine.
  • COPD:
  • ADVAIR DISKUS 250/50 is a prescription medicine used to treat COPD. COPD is a chronic lung disease that includes chronic bronchitis, emphysema, or both. ADVAIR DISKUS 250/50 is used long term as 1 inhalation 2 times each day to improve symptoms of COPD for better breathing and to reduce the number of flare-ups (the worsening of your COPD symptoms for several days).
  • Do Not Use Advair Diskus: 

    • to relieve sudden breathing problems.
    • as a rescue inhaler.
    • if you have a severe allergy to milk proteins. Ask your healthcare provider if you are not sure.
    • if you are allergic to fluticasone propionate, salmeterol, or any of the ingredients in ADVAIR DISKUS.

      Read the step-by-step instructions for using ADVAIR DISKUS at the end of this Patient Information.

      • Do notuse ADVAIR DISKUS unless your healthcare provider has taught you how to use the inhaler and you understand how to use it correctly.
      • Children should use ADVAIR DISKUS with an adult s help, as instructed by the child s healthcare provider.
      • ADVAIR DISKUS comes in 3 different strengths. Your healthcare provider prescribed the strength that is best for you.
      • Use ADVAIR DISKUS exactly as your healthcare provider tells you to use it.Do notuse ADVAIR DISKUS more often than prescribed.
      • Use 1 inhalation of ADVAIR DISKUS 2 times each day. Use ADVAIR DISKUS at the same time each day, about 12 hours apart.
      • If you miss a dose of ADVAIR DISKUS, just skip that dose. Take your next dose at your usual time. Do not take 2 doses at 1 time.
      • If you take too much ADVAIR DISKUS, call your healthcare provider or go to the nearest hospital emergency room right away if you have any unusual symptoms, such as worsening shortness of breath, chest pain, increased heart rate, or shakiness.
      • Do not use other medicines that contain a LABA for any reason.Ask your healthcare provider or pharmacist if any of your other medicines are LABA medicines.
      • Do notstop using ADVAIR DISKUS, even if you are feeling better, unless your healthcare provider tells you to.
      • ADVAIR DISKUS does not relieve sudden breathing problems.Always have a rescue inhaler with you to treat sudden symptoms. If you do not have a rescue inhaler, call your healthcare provider to have one prescribed for you.
      • Rinse your mouth with waterwithout swallowingafter each dose of ADVAIR DISKUS. This will help lessen the chance of getting a yeast infection (thrush) in your mouth and throat.
      • Call your healthcare provider or get medical care right away if:
        • your breathing problems get worse.
        • you need to use your rescue inhaler more often than usual.
        • your rescue inhaler does not work as well to relieve your symptoms.
        • you need to use 4 or more inhalations of your rescue inhaler in 24 hours for 2 or more days in a row.
        • you use 1 whole canister of your rescue inhaler in 8 weeks.
        • your peak flow meter results decrease. Your healthcare provider will tell you the numbers that are right for you.
        • you have asthma and your symptoms do not improve after using ADVAIR DISKUS regularly for 1 week.

    Advair Diskus Can Cause Serious Side Effects, Including: 

    • fungal infection in your mouth or throat (thrush).Rinse your mouth with waterwithout swallowingafter using ADVAIR DISKUS to help reduce your chance of getting thrush.
    • pneumonia.People with COPD have a higher chance of getting pneumonia. ADVAIR DISKUS may increase the chance of you getting pneumonia. Call your healthcare provider right away if you have any of the following symptoms:
    • increase in mucus (sputum) production
    • change in mucus color
    • fever
    • chills
    • increased cough
    • increased breathing problems
    • weakened immune system and increased chance of getting infections (immunosuppression).
    • reduced adrenal function (adrenal insufficiency).Adrenal insufficiency is a condition where the adrenal glands do not make enough steroid hormones. This can happen when you stop taking oral corticosteroid medicines (such as prednisone) and start taking a medicine containing an inhaled steroid (such as ADVAIR DISKUS). During this transition period, when your body is under stress such as from fever, trauma (such as a car accident), infection, surgery, or worse COPD symptoms, adrenal insufficiency can get worse and may cause death.

    Symptoms Of Adrenal Insufficiency Include: 

    • feeling tired
    • lack of energy
    • weakness
    • nausea and vomiting
    • low blood pressure (hypotension)
    • sudden breathing problems immediately after inhaling your medicine.If you have sudden breathing problems immediately after inhaling your medicine, stop using ADVAIR DISKUS and call your healthcare provider right away.
    • serious allergic reactions.Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction:
    • rash
    • hives
    • swelling of your face, mouth, and tongue
    • breathing problems
    • effects on heart.
    • increased blood pressure
    • a fast or irregular heartbeat
    • chest pain
    • effects on nervous system.
    • tremor
    • nervousness
    • bone thinning or weakness (osteoporosis).
    • slowed growth in children.Your child s growth should be checked regularly by the healthcare provider while using ADVAIR DISKUS.
    • eye problemsincluding glaucoma, increased pressure in your eye, cataracts, or other changes in vision. You should have regular eye exams while using ADVAIR DISKUS.
    • changes in laboratory blood levels (sugar, potassium, certain types of white blood cells).

    Common Side Effects Of Advair Diskus Include: 

    Asthma:

    • upper respiratory tract infection
    • throat irritation
    • hoarseness and voice changes
    • thrush in your mouth or throat. Rinse your mouth with water without swallowing after use to help prevent this.
    • bronchitis
    • cough
    • headache
    • nausea and vomiting

    In children with asthma, infections in the ear, nose, and throat are common.

    COPD:

    • thrush in your mouth or throat. Rinse your mouth with water without swallowing after use to help prevent this.
    • throat irritation
    • hoarseness and voice changes
    • viral respiratory infections
    • headache
    • muscle and bone pain

    These are not all the possible side effects of ADVAIR DISKUS.

    Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    How Should I Store Advair Diskus? 

    • Store ADVAIR DISKUS at room temperature between 68 F and 77 F (20 C and 25 C). Keep in a dry place away from heat and sunlight.
    • Store ADVAIR DISKUS in the unopened foil pouch and only open when ready for use.
    • Safely throw away ADVAIR DISKUS in the trash 1 month after you open the foil pouch or when the counter reads0, whichever comes first.

    Keep ADVAIR DISKUS and all medicines out of the reach of children.

    General information about the safe and effective use of ADVAIR DISKUS.

    Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use ADVAIR DISKUS for a condition for which it was not prescribed. Do not give ADVAIR DISKUS to other people, even if they have the same symptoms that you have. It may harm them.

    You can ask your healthcare provider or pharmacist for information about ADVAIR DISKUS that was written for health professionals.

    Active Ingredients: 

    fluticasone propionate, salmeterol xinafoate

    Inactive Ingredient: 

    lactose monohydrate (contains milk proteins)

    For more information about ADVAIR DISKUS, call 1-888-825-5249 or visit our website at www.advair.com.

    Trademarks are owned by or licensed to the GSK group of companies.

    GlaxoSmithKline, Research Triangle Park, NC 27709

    2019 GSK group of companies or its licensor.

    ADD:12PIL

    This Patient Information has been approved by the U.S. Food and Drug Administration. Revised: January 2019

    INSTRUCTIONS FOR USE

    ADVAIR DISKUS (AD vair DISK us)

    (fluticasone propionate and salmeterol inhalation powder)

    for oral inhalation use

    Read this Instructions for Use before you start using ADVAIR DISKUS and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.

    Your ADVAIR DISKUS inhaler

    Figure A
    • Figure A

    Important Information About Your Advair Diskus Inhaler: 

    • ADVAIR DISKUS is for oral inhalation use only.
    • Take ADVAIR DISKUS out of the foil pouch just before you use it for the first time. Safely throw away the pouch. The DISKUS will be in the closed position.
    • Write the date you opened the foil pouch in the first blank line on the label.

      The counter on top of the DISKUS shows you how many doses are left. After you have taken55doses (9doses from the sample or institutional pack), the numbers5to0will show in red.See Figure H.These numbers warn you there are only a few doses left and are a reminder to get a refill.

      Figure H
      • Figure H

    For Correct Use Of The Diskus, Remember: 

    • Always use the DISKUS in a level, flat position.
    • Make sure the lever firmly clicks into place.
    • Hold your breath for about 10 seconds after inhaling. Then breathe out fully.
    • After each dose, rinse your mouth with water and spit it out. Do not swallow the water.
    • Do nottake an extra dose, even if you did not taste or feel the powder.
    • Do nottake the DISKUS apart.
    • Do notwash the DISKUS.
    • Always keep the DISKUS in a dry place.
    • Do notuse the DISKUS with a spacer device.

    For more information about ADVAIR DISKUS or how to use your inhaler, call 1-888-825-5249 or visit our website at www.advair.com.

    Trademarks are owned by or licensed to the GSK group of companies.

    GlaxoSmithKline, Research Triangle Park, NC 27709

    2019 GSK group of companies or its licensor.

    ADD:5IFU

    This Instructions for Use has been approved by the U.S. Food and Drug Administration Revised: January 2019

    DRUG: ADVAIRDISKUS DISKUS

    GENERIC: fluticasone propionate and salmeterol

    DOSAGE: POWDER

    ADMINSTRATION: RESPIRATORY (INHALATION)

    NDC: 70518-0508-0

    PACKAGING: 60 in 1 INHALER

    OUTER PACKAGING: 1 in 1 CARTON

    Active Ingredient(s): 

    • FLUTICASONE PROPIONATE 500ug in 1
    • SALMETEROL XINAFOATE 50ug in 1

    Inactive Ingredient(s): 

    • LACTOSE, UNSPECIFIED FORM

    Remedy_Label

    ADVAIR DISKUS
    fluticasone propionate and salmeterol powder
    Product Information
    Product TypeHUMAN PRESCRIPTION DRUGItem Code (Source)NDC:70518-0508(NDC:0173-0697)
    Route of AdministrationRESPIRATORY (INHALATION)
    Active Ingredient/Active Moiety
    Ingredient NameBasis of StrengthStrength
    SALMETEROL XINAFOATE(UNII: 6EW8Q962A5) (SALMETEROL - UNII:2I4BC502BT)SALMETEROL50 ug
    FLUTICASONE PROPIONATE(UNII: O2GMZ0LF5W) (FLUTICASONE - UNII:CUT2W21N7U)FLUTICASONE PROPIONATE500 ug
    Inactive Ingredients
    Ingredient NameStrength
    LACTOSE, UNSPECIFIED FORM(UNII: J2B2A4N98G)
    Packaging
    #Item CodePackage DescriptionMarketing Start DateMarketing End Date
    1NDC:70518-0508-01 in 1 CARTON05/09/2017
    160 in 1 INHALER; Type 2: Prefilled Drug Delivery Device/System (syringe, patch, etc.)
    Marketing Information
    Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
    NDANDA02107705/09/2017
    Labeler -REMEDYREPACK INC. (829572556)

    Revised: 4/2019document Id: 

    8591003c-c2f7-df65-e053-2a91aa0a42fbSet id: d18ddede-c300-4ba1-8b19-055181eeed28Version: 3Effective Time: 20190402REMEDYREPACK INC.



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