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AGRYLIN- anagrelide hydrochloride capsule


  1. Patient Information
  2. Cardiovascular Effects:
  3. Risk Of Pulmonary Hypertension:
  4. Risk Of Bleeding:
  5. Lactation:
  6. Infertility:

Patient Information 

  • Dose:Tell the patient that their dose will be adjusted on a weekly basis until they are on a dose that lowers their platelets to an appropriate level. This will also help the patient to adjust to common side effects. Tell the patient to contact their doctor if they experience tolerability issues, so the dose or dosing frequency can be adjusted[seeDosage and Administration (2)].

Cardiovascular Effects: 

Tell the patient to contact a doctor immediately if they experience chest pain, palpitations, or feel their heartbeat is irregular[seeWarnings and Precautions (5.1)].

Risk Of Pulmonary Hypertension: 

Tell the patient to contact a doctor immediately if they experience shortness of breath, swelling in legs or ankles, or lips and skin turn a bluish color[seeWarnings and Precautions (5.2)].

Risk Of Bleeding: 

Warn the patient that concomitant aspirin (or other medicines that affect blood clotting) may increase the risk of bleeding. Tell the patient to contact a doctor immediately if they experience signs or symptoms of bleeding (e.g. vomit blood, pass bloody or black stools) or experience unexplained bruising/bruise more easily than usual[seeWarnings and Precautions (5.3),Drug Interactions (7.1)].

Lactation: 

Advise women not to breastfeed during treatment with AGRYLIN, and for one week following the last dose[seeUse in Specific Populations (8.2)].

Infertility: 

Advise females of reproductive potential treatment with AGRYLIN may impair fertility[seeUse in Specific Populations (8.3),Nonclinical Toxicology (13.1)].

Manufactured for Shire US Inc., 300 Shire Way, Lexington, MA 02421, USA

AGRYLINis a registered trademark of Shire LLC.

2018 Shire US Inc.

Printed in USA



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