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AVASTIN- bevacizumab injection, solution


Patient Information

Gastrointestinal Perforations and Fistulae: Avastin may increase the risk of developing gastrointestinal perforations and fistulae. Advise patients to immediately contact their health care provider for high fever, rigors, persistent or severe abdominal pain, severe constipation, or vomiting[seeWarnings and Precautions (5.1)].

Surgery and Wound Healing Complications: Avastin can increase the risk of wound healing complications. Advise patients that Avastin should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed[seeWarnings and Precautions (5.2)].

Hemorrhage: Avastin can increase the risk of hemorrhage. Advise patients to immediately contact their health care provider for signs and symptoms of serious or unusual bleeding including coughing or spitting blood[seeWarnings and Precautions (5.3)].

Arterial and Venous Thromboembolic Events: Avastin increases the risk of arterial and venous thromboembolic events. Advise patients to immediately contact their health care provider for signs and symptoms of arterial or venous thromboembolism[seeWarnings and Precautions (5.4,5.5)].

Hypertension: Avastin can increase blood pressure. Advise patients that they will undergo routine blood pressure monitoring and to contact their healthcare provider if they experience changes in blood pressure[seeWarnings and Precautions (5.6)].

Posterior Reversible Leukoencephalopathy Syndrome: Posterior reversible encephalopathy syndrome (PRES) has been associated with Avastin treatment. Advise patients to immediately contact their health care provider for new onset or worsening neurological function[seeWarnings and Precautions (5.7)].

Renal Injury and Proteinuria: Avastin increases the risk of proteinuria and renal injury, including nephrotic syndrome. Advise patients that treatment with Avastin requires regular monitoring of renal function and to contact their health care provider for proteinuria or signs and symptoms of nephrotic syndrome[seeWarnings and Precautions (5.8)].

Infusion-Related Reactions: Avastin can cause infusion-related reactions. Advise patients to contact their healthcare provider immediately for signs or symptoms of infusion-related reactions[seeWarnings and Precautions (5.9)].

Congestive Heart Failure: Avastin can increase the risk of developing congestive heart failure. Advise patients to contact their healthcare provider immediately for signs and symptoms of CHF[seeWarnings and Precautions (5.12)].

Embryo-Fetal Toxicity: Advise female patients that Avastin may cause fetal harm and to inform their healthcare provider with a known or suspected pregnancy[seeWarnings and Precautions (5.10),Use in Specific Populations (8.1)].Advise females of reproductive potential to use effective contraception during treatment with Avastin and for 6 months after the last dose[seeUse in Specific Populations (8.3)].

Ovarian Failure: Avastin may lead to ovarian failure. Advise patients of potential options for preservation of ova prior to starting treatment[seeWarnings and Precautions (5.11)].

Lactation: Advise women not to breastfeed during treatment with Avastin and for 6 months after the last dose[seeUse in Specific Populations (8.2)].

Avastin(bevacizumab)
Manufactured by:
Genentech, Inc.
A Member of the Roche Group
1 DNA Way
South San Francisco, CA 94080-4990

Avastinis a registered trademark of Genentech, Inc.
2019 Genentech, Inc.

Representative sample of labeling (see theHOW SUPPLIEDsection for complete listing):



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