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CINRYZE- human c1-esterase inhibitor injection, powder, lyophilized, for solution


  1. Patient Information
  2. Who Should Not Use Cinryze?
  3. What Should I Tell My Healthcare Provider Before Using Cinryze?
  4. Allergic Reactions May Occur With Cinryze. Call Your Healthcare Provider Or Get Emergency Support Services Right Away If You Have Any Of The Following Symptoms:
  5. Serious Blood Clots May Occur With Cinryze. Call Your Healthcare Provider Or Get Emergency Support Services Right Away If You Have Any Of The Following Symptoms:
  6. What Else Should I Know About Cinryze?

Patient Information 

CINRYZE is an injectable medicine that is used to help prevent swelling and/or painful attacks in children (6 years of age and older), teenagers and adults with Hereditary Angioedema (HAE). HAE is caused by the decreased functioning of a protein called C1 esterase inhibitor, that is present in your blood and helps control inflammation (swelling) and parts of the immune system. CINRYZE contains C1 esterase inhibitor. Before you can inject CINRYZE into your vein (intravenous injection), you must dissolve the CINRYZE powder using Sterile Water for Injection, USP. You can get supplies, including Sterile Water for Injection, USP from your pharmacist.

Who Should Not Use Cinryze? 

You should not use CINRYZE if you have had life-threatening immediate hypersensitivity reactions, including anaphylaxis, to the product.

What Should I Tell My Healthcare Provider Before Using Cinryze? 

Tell your healthcare provider about all of your medical conditions, including if you

  • have an indwelling catheter/access device in one of your veins.
  • have a history of blood clots, heart disease, or stroke.
  • are taking birth control pills or androgens.
  • are pregnant or planning to become pregnant. It is not known if CINRYZE can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if CINRYZE passes into your milk and if it can harm your baby.

Tell your healthcare provider and pharmacist about all of the medicines you take, including all prescription and non-prescription medicines such as over-the-counter medicines, supplements, or herbal remedies.

Allergic Reactions May Occur With Cinryze. Call Your Healthcare Provider Or Get Emergency Support Services Right Away If You Have Any Of The Following Symptoms: 

  • wheezing
  • difficulty breathing
  • chest tightness
  • turning blue (look at lips and gums)
  • fast heartbeat
  • swelling of the face
  • faintness
  • rash
  • hives

Serious Blood Clots May Occur With Cinryze. Call Your Healthcare Provider Or Get Emergency Support Services Right Away If You Have Any Of The Following Symptoms: 

  • pain and/or swelling of an arm or leg with warmth over the affected area
  • discoloration of an arm or leg
  • unexplained shortness of breath
  • chest pain or discomfort that worsens on deep breathing
  • unexplained rapid heart rate
  • numbness or weakness on one side of the body

The most common side effects

Do not freeze CINRYZE.

Store CINRYZE in a refrigerator or at room temperature between 36 F to 77 F (2 C to 25 C).

Keep CINRYZE in the original carton to protect it from light.

Do not use CINRYZE after the expiration date on the vial.

What Else Should I Know About Cinryze? 

Medicines are sometimes prescribed for purposes other than those listed here. Do not use CINRYZE for a condition for which it is not prescribed. Do not share CINRYZE with other people, even if they have the same symptoms that you have.

Because CINRYZE is made from human blood, it may carry a risk of transmitting infectious agents, e.g. viruses, and, theoretically, the Creutzfeldt-Jakob (CJD) agent.

This leaflet summarizes the most important information about CINRYZE. If you would like more information, talk to your healthcare provider. You can ask your healthcare provider or pharmacist for information about CINRYZE that was written for healthcare professionals.



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