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ENTRESTO- sacubitril and valsartan tablet, film coated


  1. Patient Information
  2. Pregnancy:
  3. Angioedema:

Patient Information 

Advise patients to read the FDA-approved patient labeling (Patient Information).

Pregnancy: 

Advise female patients of childbearing age about the consequences of exposure to ENTRESTO during pregnancy. Discuss treatment options with women planning to become pregnant. Ask patients to report pregnancies to their physicians as soon as possible[see Warnings and Precautions (5.1) and Use in Specific Populations (8.1)].

Angioedema: 

Advise patients to discontinue use of their previous ACE inhibitor or ARB. Advise patients to allow a 36 hour wash-out period if switching from or to an ACE inhibitor[see Contraindications (4) and Warnings and Precautions (5.2)].

T2019-106



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